Synthesis, characterization and cytotoxic activity of novel Cu(II) and Co(II) complexes with 3-amino-5, 5-dimethylhydantoin

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creativework.keywords5,5-Disubstituted hydantoins, Copper and cobalt complexes, Cytotoxic activity, Human tumor cell lines, Voltammetry
creativework.publisherElsevier Masson SAS62 rue Camille DesmoulinsIssy les Moulineaux Cedex92442infos@masson.fren
dc.contributor.authorGeorgieva S.
dc.contributor.authorTodorov P.
dc.contributor.authorWesselinova D.
dc.date.accessioned2024-07-10T14:27:03Z
dc.date.accessioned2024-07-10T14:48:05Z
dc.date.available2024-07-10T14:27:03Z
dc.date.available2024-07-10T14:48:05Z
dc.date.issued2014-01-01
dc.description.abstractNovel mixed complexes of copper (II) and cobalt (II) with 3-amino-5,5-dimethylhydantoin were synthesized and their in vitro anticancer activity was investigated. The structures of the compounds were confirmed by IR, UV-Vis spectrometry, voltammetry and elemental analysis. The cytotoxic effects of novel complexes of copper (II) and cobalt (II) with 3-amino-5,5-dimethylhydantoin were tested against a panel of human tumor cell lines. All of the compounds investigated exhibited different concentration-dependent antiproliferative effects against the HT29, MDA-MB-231, HepG2 and HeLa cell lines after 24 h of treatment. The most sensitive cells were the HepG2 cells at various concentrations of both tested compounds followed by HT29.
dc.identifier.doi10.1016/j.crci.2014.01.020
dc.identifier.issn1631-0748
dc.identifier.scopusSCOPUS_ID:84910070422en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/320
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84910070422&origin=inward
dc.titleSynthesis, characterization and cytotoxic activity of novel Cu(II) and Co(II) complexes with 3-amino-5, 5-dimethylhydantoin
dc.typeArticle
oaire.citation.issue12
oaire.citation.volume17
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