New Poly(Propylene Imine) dendrimer modified with acridine and its Cu(II) complex: Synthesis, characterization and antimicrobial activity

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creativework.keywordsAcridine, Antibacterial cotton, Antimicrobial activity, Dendrimer, Metallodendrimer
creativework.publisherMDPI AGPostfachBaselCH-4005indexing@mdpi.comen
dc.contributor.authorBosch P.
dc.contributor.authorStaneva D.
dc.contributor.authorVasileva-Tonkova E.
dc.contributor.authorGrozdanov P.
dc.contributor.authorNikolova I.
dc.contributor.authorKukeva R.
dc.contributor.authorStoyanova R.
dc.contributor.authorGrabchev I.
dc.date.accessioned2024-07-10T14:27:04Z
dc.date.accessioned2024-07-10T14:49:30Z
dc.date.available2024-07-10T14:27:04Z
dc.date.available2024-07-10T14:49:30Z
dc.date.issued2019-09-01
dc.description.abstractA second-generation poly(propylene imine) dendrimer modified with acridine and its Cu(II) complex have been synthesized for the first time. It has been found that two copper ions form complexes with the nitrogen atoms of the dendrimeric core by coordinate bonds. The new compounds have been characterized by nuclear magnetic resonance (NMR), electron paramagnetic resonance (EPR), fourier-transform infrared spectroscopy (FTIR) and fluorescence spectroscopy. The spectral characteristics of the modified dendrimer have been measured in different organic solvents, and a negative fluorescence solvatochromism has been observed. The antimicrobial activity of the dendrimers has been tested against model pathogenic microorganisms in agar and by broth dilution method. The cotton fabric treated with both dendrimers has been evaluated towards pathogenic microorganisms. The obtained modified cotton fabrics have been shown to hamper bacterial growth and to prevent biofilm formation. Dendrimer cytotoxicity has been investigated in vitro in the model HEp-2 cell line.
dc.identifier.doi10.3390/ma12183020
dc.identifier.issn1996-1944
dc.identifier.scopusSCOPUS_ID:85072564514en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/546
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85072564514&origin=inward
dc.titleNew Poly(Propylene Imine) dendrimer modified with acridine and its Cu(II) complex: Synthesis, characterization and antimicrobial activity
dc.typeArticle
oaire.citation.issue18
oaire.citation.volume12
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