Cytotoxicity and antibiofilm activity of SiO2/cellulose derivative hybrid materials containing silver nanoparticles

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creativework.keywordsAntibacterial activity, Cell adhesion, Cytotoxicity, Silica hybrid materials, Silver nanoparticles, Tissue engineering
creativework.publisherScientific and Technical Research Council of Turkeyen
dc.contributor.authorAngelova T.
dc.contributor.authorRangelova N.
dc.contributor.authorUzunova V.
dc.contributor.authorGeorgieva N.
dc.contributor.authorAndreeva T.
dc.contributor.authorMomchilova A.
dc.contributor.authorTzoneva R.
dc.contributor.authorMüller R.
dc.date.accessioned2024-07-10T14:27:03Z
dc.date.accessioned2024-07-10T14:48:35Z
dc.date.available2024-07-10T14:27:03Z
dc.date.available2024-07-10T14:48:35Z
dc.date.issued2016-01-01
dc.description.abstractHybrid materials based on tetraethyl orthosilicate (TEOS), hydroxypropyl cellulose (HPC), or hydroxypropyl methyl cellulose (HPMC) with silver nanoparticles were synthesized. They were analyzed and characterized using differential thermal analysis and thermogravimetry, atomic force microscopy, and static contact angle measurements. It was experimentally demonstrated that the silverdoped hybrid materials have pronounced antibacterial behavior by studying the reduction of Pseudomonas aeruginosa PAO1 biofilm formation on the tested materials. The results revealed biofilm reduction of 35.7% and 30% by SiO2/HPC/2.5% Ag and SiO2/HPMC/2.5% Ag hybrid materials, respectively, compared to the control. Cytotoxicity of examined materials and actin cytoskeleton organization of fibroblasts seeded on the materials was studied as a function of material properties as the type of surface functional groups and silver content. The obtained hybrid materials with low silver content proved efficient in tissue engineering applications since they showed good antibacterial and noncytotoxic properties for eukaryotic cells.
dc.identifier.doi10.3906/biy-1601-68
dc.identifier.issn1303-6092
dc.identifier.issn1300-0152
dc.identifier.scopusSCOPUS_ID:85007283621en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/411
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85007283621&origin=inward
dc.titleCytotoxicity and antibiofilm activity of SiO2/cellulose derivative hybrid materials containing silver nanoparticles
dc.typeArticle
oaire.citation.issue6
oaire.citation.volume40
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