THERMAL PROPERTIES OF PVA/TEOS/AgNps THIN HYBRID FILMS AND THEIR FUNGICIDAL ACTIVITY TOWARDS REPRESENTATIVES OF GENUS CANDIDA
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2022-01-01
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Abstract
The role of Candida infections in patients with weakened immune systems or hospitalized and catheterized patients is a worldwide problem with increasing importance. Due to the high fungal resistance to different type antifungals drugs, nowadays, the attention is paid towards novel hybrid coatings possessing strong antibacterial and fungicidal properties. The present article deals with the thermal behavior and fungicidal properties of novel hybrid materials based on polyvinyl alcohol (PVA)/tetraethyl orthosilicate (TEOS) films with included silver nanoparticles (AgNps) synthesized by sol-gel method. Thermal properties of the hybrid materials were investigated using TGA and DSC analysis. The fungicidal activity of the synthesized hybrid materials with included silver nanoparticles were tested onto control and clinical strains of genus Candida resistant to different antifungals. The antifungal activity of the synthesized materials was determined by Disk Diffusion Method (DDM) were the zone of inhibition of hybrid materials against control and clinical strains was monitoring.