CYTOTOXICITY OF COPPER DOPED SiO2-HYDROXYPROPYL CELLULOSE COMPOSITES ON CANCER AND NON-CANCEROUS CELLS
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2023-01-01
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Abstract
In the present paper the cytotoxicity of series of sol-gel based copper doped SiO2/HPC composites on lung cancer cell line (A549) and primary human umbilical cord endothelial cells (HUVEC) was investigated. Hydroxypropyl cellulose (HPC), tetraethyl ortosilicate (TEOS) were used for preparation of amorphous matrix in which the copper was added as Cu(NO3)2*3H2O or CuSO4*5H2O in concentration range of 0 - 5 wt. %. We observed that the composite materials at low concentration of Cu (0.5 wt. %) showed no toxic effects on both cell types. The composite material with CuSO4*5H2O was found relatively more toxic, and furthermore, cancer cells are more sensitive to the copper concentration increase to non-cancer cells. The concentration of Cu ions of 2.5 and 5 wt. % were toxic to both cancer and non-cancer cells at 24th hour. At 72th hour of incubation some restoration of cell viability was observed