RADICAL-SCAVENGING ACTIVITY OF (KLAKLAK)2 BIOCONJUGATES WITH CAFFEIC ACID
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2025-11-02
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Abstract
Free oxygen radicals released in the body because of various metabolic processes could lead to the so-called oxidative stress in cells, which is a precursor to various types of cancer. Protecting cells from oxidative stress is an important step in the prevention of cancer. Nature has a large supply of compounds with powerful antioxidant properties. One of them is caffeic acid. In the present study, caffeic acid was combined to obtain bioconjugates with analogues of the natural peptide with proven antitumor properties (KLAKLAK)2. Here we report the antioxidant potential of these molecules as it was investigated with the well-known from the literature DPPH method, in search of a synergistic effect between the two pharmacophores of the molecule. The obtained results identify Si18 (Caf-(KnLAKnLAK)2-NH2) as the lead candidate approaching the caffeic acid benchmark under the tested conditions with EC50 = 0.0178 mM.