PEPTIDES AND PEPTIDOMIMETICS IN NEUROPHARMACOLOGY (REVIEW)
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Date
2023-01-01
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85187493531&origin=inward
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Abstract
Peptides and peptidomimetics are a major field of bioorganic chemistry research. We endeavored to describe the current trends in medicinal and bioorganic chemistry regarding the design of drug molecules which are peptide mimetics. To this end, we reviewed the literature regarding peptidomimetics classification, new research data on innovative potential drug molecules, current research, and its perspectives. Potential or current neuropharmacological agents that possess a peptide bond in their molecules and can be used in the treatment of pain or Alzheimer’s disease are of particular interest to our study. The inclusion criteria required that the studies explore peptides, peptide mimetics, and peptidomimetics or mimetics of peptides that show biological activity in the central/peripheral nervous system. Electronic search strategies were developed and undertaken, and relevant articles were selected and reviewed. A considerable number of pharmacological agents showing pharmacotherapeutic relevance were identified and reviewed regarding biological activity in the nervous system. The ones more closely reviewed are prospective or proven effective neuropharmacological agents that are analogs of peptides/oligopeptides. The potential for discovery of various peptides and peptidomimetics, which can affect the pathogenesis of pain, neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease and others) offers to broaden the scientific horizon; in the end leading to the synthesis of potential alternatives to current pharmacotherapeutics. Translational research can be encouraged after careful consideration of the risk-benefit ratio.