NEW DERIVATIVES OF GALANTHAMINE CONTAINING PEPTIDE FRAGMENT
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2020-01-01
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Abstract
New derivatives of galanthamine containing a peptide fragment with an antiaggregation activity are synthesized. Herein the process of synthesis, purification and characterization of the newly obtained compounds is described. Syntheses were performed by consecutive attachment of Boc-protected amino acids to either norgalanthamine or HGly-Ogal using TBTU/DIPEA and TCTU/DIPEA methods. The purification of final products was realized by treating with EtOAc or by HPLC. The newly compounds were characterized by TLC, NMR, m.p. and MS. Two pharmacological effects are expected to be combined in a single molecule: the anticholinesterase and the antiaggregation ones