NEW DERIVATIVES OF GALANTHAMINE CONTAINING PEPTIDE FRAGMENT

Simple item page
creativework.keywordsAcetylcholinesterase, Alzheimer’s disease, Antiaggregation activity, Galanthamine, Norgalanthamine
creativework.publisherUniversity of Chemical Technology and Metallurgyen
dc.contributor.authorVezenkov L.
dc.contributor.authorCena H.
dc.contributor.authorDanalev D.
dc.contributor.authorKaradjova V.
dc.contributor.authorTsekova D.
dc.contributor.authorBardarov V.
dc.contributor.authorVassilev N.
dc.date.accessioned2024-07-16T11:16:51Z
dc.date.accessioned2024-07-16T11:19:28Z
dc.date.available2024-07-16T11:16:51Z
dc.date.available2024-07-16T11:19:28Z
dc.date.issued2020-01-01
dc.description.abstractNew derivatives of galanthamine containing a peptide fragment with an antiaggregation activity are synthesized. Herein the process of synthesis, purification and characterization of the newly obtained compounds is described. Syntheses were performed by consecutive attachment of Boc-protected amino acids to either norgalanthamine or HGly-Ogal using TBTU/DIPEA and TCTU/DIPEA methods. The purification of final products was realized by treating with EtOAc or by HPLC. The newly compounds were characterized by TLC, NMR, m.p. and MS. Two pharmacological effects are expected to be combined in a single molecule: the anticholinesterase and the antiaggregation ones
dc.identifier.issn1314-7978
dc.identifier.issn1314-7471
dc.identifier.scopusSCOPUS_ID:85129316074en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/1380
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85129316074&origin=inward
dc.titleNEW DERIVATIVES OF GALANTHAMINE CONTAINING PEPTIDE FRAGMENT
dc.typeArticle
oaire.citation.issue2
oaire.citation.volume55
Files
Collections
Articles