The influence of solvents on the molecular structure and biological activity of N, N/-bis(N-nicotinoyl-L-valyl)-diaminohexane
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2013-12-17
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Abstract
A peptidomimetic, N, N/-bis(N-nicotinoyl-L-valyl)-diaminohexane (M6) dissolved in identical concentration in three different types of solvent - sunflower oil, water and dimethyl sulfoxide (DMSO) was used for in vivo experiments with rats. Water and oil solutions did not provoke any symptoms of intoxication, while gross renal and hepatic toxicity was found when using DMSO solution. UV studies of M6 in several solvents, including water and DMSO showed solvatochromic shifts, due to intermolecular solvent-solute non-covalent interactions.