The influence of solvents on the molecular structure and biological activity of N, N/-bis(N-nicotinoyl-L-valyl)-diaminohexane

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creativework.keywordsPeptidomimetic, Solvatochromism, Toxicity, UV adsorption
dc.contributor.authorTsekova D.S.
dc.contributor.authorKlissurov R.
dc.contributor.authorTancheva L.
dc.contributor.authorEncheva E.
dc.contributor.authorGenadieva M.
dc.date.accessioned2024-07-16T11:16:45Z
dc.date.accessioned2024-07-16T11:17:53Z
dc.date.available2024-07-16T11:16:45Z
dc.date.available2024-07-16T11:17:53Z
dc.date.issued2013-12-17
dc.description.abstractA peptidomimetic, N, N/-bis(N-nicotinoyl-L-valyl)-diaminohexane (M6) dissolved in identical concentration in three different types of solvent - sunflower oil, water and dimethyl sulfoxide (DMSO) was used for in vivo experiments with rats. Water and oil solutions did not provoke any symptoms of intoxication, while gross renal and hepatic toxicity was found when using DMSO solution. UV studies of M6 in several solvents, including water and DMSO showed solvatochromic shifts, due to intermolecular solvent-solute non-covalent interactions.
dc.identifier.issn1314-7471
dc.identifier.issn1314-7978
dc.identifier.scopusSCOPUS_ID:84890133342en
dc.identifier.urihttps://rlib.uctm.edu/handle/123456789/1019
dc.language.isoen
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84890133342&origin=inward
dc.titleThe influence of solvents on the molecular structure and biological activity of N, N/-bis(N-nicotinoyl-L-valyl)-diaminohexane
dc.typeArticle
oaire.citation.issue6
oaire.citation.volume48
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